2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2806
    Pyruvate Kinase, Microorganism 9001-59-6
    Pyruvate Kinase, Microorganism (PK) is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP.
    Pyruvate Kinase, Microorganism
  • HY-113026
    Delta-Tocopherol 119-13-1 ≥98.0%
    Delta-Tocopherol is an isomer of Vitamin E.
    Delta-Tocopherol
  • HY-113162
    Bovinic acid 2540-56-9 ≥99.0%
    Bovinic acid is a conjugated linoleic acid with anticarcinogenic and anti-atherogenic activities.
    Bovinic acid
  • HY-113266
    Valerylcarnitine 40225-14-7 ≥99.0%
    Valerylcarnitine is an endogenous metabolite, belonging to the short-chain acylcarnitines.
    Valerylcarnitine
  • HY-113283
    Homogentisic acid 451-13-8 ≥98.0%
    Homogentisic acid is a specific metabolite in urine and serum, which is used for diagnosis of alkaptonuria.
    Homogentisic acid
  • HY-113371
    2-Methylcitric acid 6061-96-7
    2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
    2-Methylcitric acid
  • HY-113373
    Guanidinosuccinic acid 6133-30-8 ≥98.0%
    Guanidinosuccinic acid is a nitrogenous metabolite.
    Guanidinosuccinic acid
  • HY-115642
    preQ1 dihydrochloride 86694-45-3 ≥98.0%
    preQ1 dihydrochloride is a modified, guanine-derived nucleobase and a precursor of Queuine (HY-N10574) biosynthesis. preQ1 dihydrochloride binds to the aptamer of PreQ1 riboswitch with high affinity.
    preQ1 dihydrochloride
  • HY-125145
    AA92593 457961-34-1 99.94%
    AA92593 is a selective and competitive melanopsin OPN4 antagonist.
    AA92593
  • HY-128425
    N-​Carbamoyl-​DL-​aspartic acid 923-37-5 ≥98.0%
    N-​Carbamoyl-​DL-​aspartic acid (Ureidosuccinic acid) is a precursor of nucleic acid pyrimidines. N-​Carbamoyl-​DL-​aspartic acid has antitumor activities.
    N-​Carbamoyl-​DL-​aspartic acid
  • HY-148814
    BI-3231 2894848-07-6 99.83%
    BI 3231 is a potent and selective hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases.
    BI-3231
  • HY-151257
    IHMT-MST1-58 2414484-25-4 99.05%
    IHMT-MST1-58 is a potent, selective mammalian and orally active STE20-like protein 1 kinase (MST1) inhibitor with IC50 value of 23 nM. IHMT-MST1-58 can be used for the research of Type 1/2 diabetes.
    IHMT-MST1-58
  • HY-152221
    PCSK9-IN-10 368434-98-4 98.95%
    PCSK9-IN-10 is a potent and orally active PCSK9 inhibitor with an IC50 value of 6.4 µM. PCSK9-IN-10 increases the expression of LDLR protein and decreases the expression of PCSK9. PCSK9-IN-10 reduces atherosclerosis progression. PCSK9-IN-10 has the potential for the research of hyperlipidemia.
    PCSK9-IN-10
  • HY-15687A
    SAR407899 923359-38-0 99.60%
    SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. SAR407899 shows stable inhibition of migrasome formation.
    SAR407899
  • HY-18101A
    BD1063 dhydrochloride 206996-13-6 ≥98.0%
    BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.
    BD1063 dhydrochloride
  • HY-106376C
    L-Buthionine-(S,R)-sulfoximine hydrochloride ≥98.0%
    L-Buthionine-(S,R)-sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
    L-Buthionine-(S,R)-sulfoximine hydrochloride
  • HY-113920A
    Azumolene 64748-79-4 99.11%
    Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research.
    Azumolene
  • HY-128851B
    Coenzyme A sodium 55672-92-9 99.46%
    Coenzyme A (CoASH) sodium is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids.
    Coenzyme A sodium
  • HY-145934A
    UDP-GlcNAz disodium 1611490-64-2 99.74%
    UDP-GlcNAz disodium (UDP-N-azidoacetylgalactosamine disodium) is the analogue of UDP-GlcNAc (HY-112174). UDP-GlcNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GlcNAc from the nucleotide sugar to a saccharide or peptide acceptor. UDP-GlcNAc (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    UDP-GlcNAz disodium
  • HY-N0623S2
    L-Tryptophan-13C11 202114-65-6 99.60%
    L-Tryptophan-13C11 is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3.
    L-Tryptophan-13C11
Cat. No. Product Name / Synonyms Application Reactivity